The Office of the Director-General/Chief Executive oversees the entire Institute, with two (2) non-technical departments, which are (i) Department of Human Resources Management, and (ii) Department of Finance & Accounts. 

But however, the Director General’s Office has Units directly under its supervision. These Units include;

1. Audit

2. Legal

3. Planning, Monitoring & Evaluation

4. Protocol/Public Relation

5. Library, Information & Documentation Services

6. Procurement

7. Information & Communication Technology

8. NIPRD Research Clinic

9. SERVICOM

10. Consultancy Services

Key laboratories under the supervision of the Office of the Director-General / Chief Executive include;

1. Central Laboratory Facility

2. NIH/NIPRD Laboratory